科学家发现DNA损伤和癌症之间有新的联系 2018-10-11 编辑:lverson_zp (中国国际电视台)

双语

导读:澳大利亚和荷兰科学家的一项新研究通过发现早发性白血病背后的潜在原因,强调了DNA损伤和癌症之间的联系。

科学家发现DNA损伤和癌症之间有新的联系_双语新闻

New research by Australian and Dutch scientists has highlighted a link between DNA damage and cancer, by identifying an underlying cause behind early onset leukemia.

澳大利亚和荷兰科学家的一项新研究通过发现早发性白血病背后的潜在原因,强调了DNA损伤和癌症之间的联系。

Released on Friday, the study was led by scientists at Melbourne’s Walter and Eliza Hall Institute of Medical Research (WEHI), in collaboration with colleagues at Erasmus University Medical Center in the Netherlands.

该研究于上周五公布,由墨尔本沃尔特霍尔医学研究所的科学家和荷兰伊拉斯谟大学医学中心的同事共同领导。

The study used samples from three, roughly 30-year-old patients, with an unusual early-onset form of acute myeloid leukemia (AML), which normally appears in patients around the age of 70.

这项研究使用了三名30岁左右的患者的样本,他们患有一种罕见的早期急性髓系白血病(AML),通常出现在70岁左右的患者身上。

They found that the younger patients all lacked a DNA repair protein called MBD4 which led to them accumulating DNA damage at a higher rate than normal, as though they were aging prematurely.

他们发现,年轻的患者都缺乏一种名为MBD4的DNA修复蛋白,这导致他们的DNA损伤积累率高于正常水平,就好像他们过早衰老了一样。

"When we sequenced the patients’ genomes, we discovered they all carried changes in the same gene, called MBD4, a gene which encodes a protein that repairs methylation damage," co-lead researcher Edward Chew said.

“当我们对患者的基因组进行测序时,我们发现他们都携带了相同基因MBD4的变化,这是一种编码蛋白质的基因,可以修复甲基化损伤,”共同牵头的研究人员Edward Chew说。

"The loss of MBD4 in these patients explained why their cells had not repaired the damage," the doctor said.

“在这些患者中,MBD4的缺失解释了为什么他们的细胞没有修复损伤,”医生说。

All cancers are caused by changes to a cell’s genome and as a person ages, their DNA accumulates damage, which can cause these changes and increase the risk of developing cancer.

所有的癌症都是由细胞基因组的变化引起的,随着一个人年龄的增长,他们的DNA会累积损害,这会导致这些变化,增加患癌症的风险。

"The three patients who lacked MBD4 were predisposed to accumulating high rates of methylation damage – which we believe led to them developing AML as young adults," Chew said.

“三名缺乏MBD4的患者很容易积累高的甲基化损伤率,我们认为这导致他们在年轻时发展为AML,”Chew说。

As this latest study has determined, methylation damage has a particularly strong link with blood cancers, such as leukemia. According to the team, an important next step is to understand precisely why blood cells are at risk from that form of DNA damage.

正如这项最新研究确定的那样,甲基化损伤与血癌(如白血病)有着特别密切的联系。根据研究小组的说法,下面很重要的一步是准确解释为什么血细胞会受到这种形式的DNA损伤的威胁。

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